Collaborating across disciplines and organizations to create a change at a larger scale requires taking an "ecosystem" view. Similarly, to create transformative change, rather than tinkering with symptoms of a problem, one needs to understand the dynamics of the system. Systems have common principles and patterns of activity that keep them functioning and performing consistently. Understanding these patterns is critical to identifying the leverage points for change and appreciating how parts of the system affect each other.
The key to innovation is always to manage a subtle balance of planning, structure, and improvisation.